Genome Guardian 2

Genome Guardian 2

Alpherior · 2026 · Gun Customization, Bullet Heaven, Roguelite, Action, Casual

PC
Very Positive97% · 365
Best price
$15.99
lowest tracked $11.19
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Standard Edition · Steam
$15.99
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About Genome Guardian 2

Dive back into the microscopic world, radiating with bioluminescent life and unspeakable horrors.

Research permanent upgrades to survive a variety of microbes & modes in this massively expanded follow-up to Genome Guardian.

Build your own biomechanical death machine from different parts to define how it shoots, behaves & moves!

Make stationary turrets, psychic water sprinkler motorbikes, or maybe a dual-wielding fidget spinner Gundam.
  • Easily recreate your favourite turrets from the first game…or combine em' all into one frankenstein monstrosity
  • Save/Load 24 loadouts
  • Paint & Pattern customization

Pair DNA nucleotides A (rapidfire), C (precision), G (spread), T (explosive) to discover 70 hybrid bioweapons!

  • Shotgun + Bomb mix explosives with spread for Blast Shotgun!
  • SMG + Pistol make an accurate, fast-firing Scout Rifle!
  • Blast Shotgun + Scout Rifle = something a whole lot crazier!
  • 20-minute runs you can save & resume at any time + improved Endless Mode
  • Complete side objectives during runs for extra cash
  • Mine mineral deposits for resources
  • Trigger powerful Gadget active abilities
  • Test discovered weapons in the Database
  • 100 bassy electronic tunes with in-game Jukebox accessible any time + Streamer Mode
  • Auto aim/fire toggles
  • Localization in 10 languages
  • Full rebinding for keyboard & gamepad
  • 400% better performance/framerate on high & low-end PCs
  • Accessibility for colourblindness, motion sickness & arachnophobia
  • 100 Steam achievements
  • Cloud Save
  • Plays great on Steam Deck!

What Steam players say

Recent verbatim reviews from Steam — separate from playze.io community reviews below.

Recommended Jul 24, 2026
This is the type of game that makes other games redundant. I don't think I'm ever going to use the word perfect in reference to a game unless it's this game here.
1 found this helpful
Recommended Jul 23, 2026
have you ever wanted to piece together an absolutely wicked build idea with the pieces you've grabbed? probably? well this is the game for you! loads of different parts, mechanics and gimmicks to build around and primarily focus on in this game... i find a lot of the fun here to be messing around and tinkering with all the parts that modify your bullets and such
1 found this helpful
Recommended Jul 25, 2026
actual peak game already
Recommended Jul 22, 2026
An absolute blast of a rougelite with so many fun ways to make your screen a lot of pretty colors
Recommended Jul 21, 2026
Straightforward twin-stick roguelite with loads of combinations for equipment and their effects. Has quite an amount of options for adjusting the game to taste. You can even turn it into a Survivors-like with separate options for auto-aim AND auto-fire. It's like Crimsonland and Brotato had a baby. Killing things without interruption, mess with your build inbetween waves. Some "characters" can't move while others are quite mobile in their own ways. There's metaprogression in two different ways. 1) Incremental changes such as + damage, accuracy, more rerolls, etc. And 2) Parts to permanently unlock that you can toy around with. This can get rather intricate, so they've even included a generous loadout system with a ton of save slots. You can disable the screen shaking and vibrations or even turn it all the way up. It's quite trippy and gets you in a groove, though can be a little bit of an eyestrain over lengthy play.
Recommended Jul 20, 2026
If you're like, "man, I wish I could capture the magic of games like Centipede or Space Invaders but with all the bells and whistles of modernity and basically infinite replayability through both roguelite progression and just sheer volume of things to do" -- you're home. Install. Thank us all later in the Discord. If you're not thinking that, I ... hunh. I guess you're too young to remember Centipede and Space Invaders? That's adorable. Buy this game, it's, uh... it's like if Geometry Dash took the drugs your parents keep telling you are bad. Which, like, don't do those, they're bad. But this game isn't? Yeah.

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