Pathogenic
Aberrant Labs · 2026 · Bullet Hell, Local Co-Op, Action Roguelike, Roguelike, Dungeon Crawler
PC
Overwhelmingly Positive95% · 1,097
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About Pathogenic
CELLULAR COMBAT EVOLVEDIn Pathogenic, you are the disease. Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and conquer your human host.To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction. Create powerful, game-breaking builds and become the ultimate pathogen.CREATE YOUR OWN PATHOGENLoot, graft, and assemble your parasite from dozens of unique organelles. Combine flagella for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Chain organelle effects and discover powerful synergies to build an unstoppable disease vector.FIGHT THE IMMUNE SYSTEMBattle a diverse roster of enemies, from basic immune cells like macrophages and T cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.METAPROGRESSIONCollect plasmid fragments to permanently upgrade your parasite's plasmid tree between runs. Each parasite will have it's own upgrade tree allowing for a range of builds to suit your preferred playstyle.EXPLORE A MICROSCOPIC WORLDNavigate the procedurally generated organic landscape of the human body. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.FEEL THE ORGANIC ACTIONOur detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures endless variety - each run offers a fresh and challenging gameplay experience.JOIN OUR COMMUNITY ON DISCORD
DLC & expansions
What Steam players say
Recent verbatim reviews from Steam — separate from playze.io community reviews below.
splendid
Who could have guessed that internal human anatomy was a mid 90's glowstick rave? Biology is fascinating. 10/10
Ignoring the playful opening and ending, the game itself is actually quite good. The excellent combat feel and controls, deep build variety, and the interactions between different organelles kept me playing the DEMO for nearly 100 hours. However, the main problem lies in the beginning and the ending, which weaken the sense of purpose built throughout the game. The UI, music, and overall system design consistently create the feeling of a professional biological experiment, but the story does not follow through with that direction, creating a clear disconnect between the gameplay and the narrative. Especially the virus editing interface: the body temperature, pulse, and various biological parameters made me believe that I was participating in a simulation of a human environment and conducting virus research. The process of modifying virus traits, observing results, and optimizing builds feels like a serious scientific experiment. However, the opening cutscene already tells the player that they are simply a virus that accidentally entered a human body. After spending hours researching, modifying, and evolving the virus, what exactly are all those experimental parameters supposed to…
I played several hours of the demo and have been waiting for the game to drop. So glad its finally here. The gameplay fun, music is addicting, love the customization of my parasite. (I like going melee) I highly recommend anyone to buy this game. It is so well made.
great stuff
Awesome fun game. Great particle effects. Good music. Looks amazing/ runs amazing on steam deck. Aside from a slight slowdown when lots of things are on the screen, very minor. ehhhh for the evolutions I don't find myself choosing to evolve alot of the times. Almost seems like a direct negative most of the time. Bigger fatter and slower means you're more likely to get hit. Maybe make the cell more jelly like and able to slim down during movement, would allow for some neat feeling dodges.
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