

Genome Guardian
Alpherior · 2024 · Action Roguelike, Shooter, Roguelite, Gun Customization, Roguelike
PC
Very Positive92% · 706
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About Genome Guardian
Dive into the microscopic world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".
Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
- Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
- Bomb + Bomb doubles down on explosive power to make Bazooka!
- Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!
- 49 Turrets with unique strengths and functions
- 96 Perks to mix and match that drastically change how you play
- 75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs
- 64 Mutations alter the challenges you face each run
- 20-minute Runs that can be continued in Endless Mode
- 75 Bassy Electronic Tunes that adapt to the current mood & intensity
- Cosmetics like spider legs and tank tread
- Accessibility Settings for colourblindness, motion sickness, and even arachnophobia!
- 100 Steam Achievements
- Steam Trading Cards
- Cloud Save
- Plays great on Steam Deck!!!
What Steam players say
Recent verbatim reviews from Steam — separate from playze.io community reviews below.
Yes, you will buy this game. Yes, you will love this game. I have exactly zero complaints. All the problems I do have, come from my own lack of skill or game knowledge, and it's so obvious... That's the first time a game has been so black and white about what is your fault and what is going wrong because of bad game design. I haven't seen any bad game design so far. Also, the music in here is like crack. You guys should look into expanding the track list a bit, or maybe a feature to allow our own music to kind of sync up with the game? It's a real basic visual sync that goes off just peak beats vs trying to match the whole song.
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is gud, ja?
this game is so dang fun when it comes to all the weapon customizations, i havent even gotten halfway and i unlocked the jocker tower and it sped run me through the game and i ended with like 3k moneys and honestly was astounded by the randomized gameplay, this is one of the most replayable games ive ever seen with a few thousand hours of gaming
Glitch that ruined my run in second to last wave aside, it's been just meh. wouldn't've bought the game if I didn't like the idea of unlocking all the different weapon combinations and filling out the meta progression, but it turned out disappointingly dull. I did like trying the combinations and filling out the weapon arsenal at first, but even that gets old real fast tbh, the meta progression is easily maxed out in a couple of hours and all that's left are the same monotonous runs, there are barely any roguelike factors that can make your run schizo fun. Even when you demolish everything on your screen, the amount of waves you have to sit through for some of the achievements is way too high and takes long while being unfun even if you want something to afk in while enjoying podcasts/music.
rockin little defense game. big fan of the permutation gimmick. ♥♥♥♥ rocks.
Community reviews
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