

SIDE EFFECTS
hirohun · 2025 · Strategy, Gambling, Horror, Dark, 3D
PC
Very Positive83% · 810
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About SIDE EFFECTS
Up to four test subjects. One twisted medical trial. Only one leaves.
Welcome to Side Effects: a tense, turn-based medical roulette game. Each round you'll be presented with a selection of pills. Some are helpful, some are harmful, and some mean instant death. You never know what you're about to consume or what it might do to your mind or body. Winning means outlasting – AKA, outliving – your opponent across the table.Resist
Every pill impacts your resistance. Manage it wisely: zero resistance means death.Experiment
Between rounds, you can choose from a range of experimental items and treatments that can shift the odds in your favor, from vaccines to mouth clamps.You’re not alone
The other patient wants to outlast you. They’ll bluff, adapt, and use everything at their disposal to keep breathing one dose longer than you.Would you like to participate?This trial includes:
- A single player mode
- A multiplayer mode (2-4 Players)
- 15+ unique items
- 6 pill types to test
What Steam players say
Recent verbatim reviews from Steam — separate from playze.io community reviews below.
i love forcing my friends to eat cyanide pills3 found this helpful
its fun but not like. longterm fun. its like play for an hour with your friends fun2 found this helpful
really good i enjoyed it
8/10 Friendslop, pretty fun, basically shotgun roulette with pills
incredible
very fun multiplayer
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