S.E.M.I. – Side Effects May Include...
Two Horn Unicorn · 2026 · Co-op, Platformer, Physics, Multiplayer, Online Co-Op
PC
Mostly Positive78% · 46
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About S.E.M.I. – Side Effects May Include...
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here, you and up to 3 of your brainless loyal friends play as patients, fighting staff and other patients while stumbling into all sorts of unexpected situations. Brawls, side-effect pills, and brutal platforming will absolutely challenge your clumsy friends’ hands sense of teamwork. Expect obstacles, puzzles, deadly traps, and rooms where a single wrong move can knock out the entire squad.Communicate in voice chat and arrange sabotage help your friends pass through rooms, get out of traps and fight with opponents! In your arsenal: close combat, physics, amazing abilities and ... imagination!Take pills and get abilities:
- Bipolar force is an invulnerable monster, then a helpless rag!
- Laser astigmatism — two sights, one laser… Where will he shoot?
- Stendhal syndrome — are you looking at a painting? Now you're hysterical and destroying everything around you!
- Alice's syndrome is either tiny or gigantic — have time to adjust!
DLC & expansions
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What Steam players say
Recent verbatim reviews from Steam — separate from playze.io community reviews below.
S.E.M.I is pretty fun! I wish i had friends that had it but it works singleplayer as well! However using a controller i didnt know some of the controls such as throwing until i tried holding RT. (Only used cohntroller because my right hand is shakey as hell and makes it hard to use the mouse) 9/102 found this helpful
So fun game to play with friends. U actually have to use brain. The only real issue I had was motion blur. If you have it turned off, it still feels on at times, which can grate during fast motion. I just hope the devs take it out completely in an update. Overall, a very fun co-op game 8/10
I honestly love how goofy this game is. It is so much fun! I love the different 'side effects' and the customisation of the characters. The puzzles are funny too, I don't find them stressful. All in all I find this is a nice chill game!
[h1]Weird but Fun Platformer![/h1] This one was definitely fun with friends. We did have someone who wasn't the best at platformers, but think we all enjoyed it! The Puzzles were challenging and the effects from the "medicines" had some interesting effects. I'd recommend if you want a game to play with a group of friends!
This game is pure chaos. Its a lot of fun with close friends. The pill side effects are hysterical and the puzzles are interesting enough that you can get stuck. The way you are downed is so stupid and funny we spent to much time just hurting each other. 10/10 game experience.
Played this with my wife and we had a surprisingly good time. It can be a bit difficult at first, but that actually makes it more satisfying once you get the hang of it. The overall theme of the game is completely crazy (sorry… couldn’t resist the pun 😅), and the unpredictable abilities and side effects make every run feel chaotic in a fun way. I really like the customization options and the general design of the game. The art style and characters are pretty cool, and unlocking new outfits and decorations adds a nice extra layer to the experience. The idea behind the game is also quite original. Running through rooms, dealing with traps, fighting enemies, and dealing with random pill side effects keeps things unpredictable and entertaining the whole time. The levels and challenges keep you busy and engaged, especially when playing together. Overall, a fun and weird co-op experience that’s great to play with friends or your partner.
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