Listeria Wars

Listeria Wars

Rubel Games · 2022 · Indie, Strategy, Singleplayer, Tower Defense, RTS

PC
Positive96% · 26
Best price 68 Great deal
$0.86-80%
lowest tracked $0.83
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Steam
Steam
Standard Edition · Steam
-80%
$1.18
$5.90
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Gameseal
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Standard Edition · Steam
$0.86
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About Listeria Wars

Listeria Wars is a real-time tactical game. You defend against the pathogenic microbes, attacking a single, infected organism. A key feature of Listeria Wars is the parallel viewing experience. In addition to the main game process, you can view the life of the human whose body has become the pathogenic battlefield.

The action in Listeria Wars takes place within the hero's body. You can see everything that happens to the host’s body in real-time. You manage various types of immune system cells, to protect the body and fend off attacks, from deadly contagions. The body’s immune system develops antibodies, as the action takes place.
The game illustrates a person’s ability to be his own worst enemy: by neglecting personal hygiene, or ingesting rotten food, or failing to follow “social distancing”. You can also view the body’s use of involuntary immune system responses, such as vomiting and diarrhea. The goal is to protect and defend the infected body, from the deadly pathogens.

Key features:

  • FUNNY ADVENTURES OF THE HERO: Watch the effects of malicious pathogens and influence the immune system’s response.
  • CONVENIENT MANAGEMENT: Leukocytes attack intuitively, depending on the situation. Gamers can place these cells strategically and monitor the overall course of defense.
  • PATHOGEN DIVERSITY: Realistic infections, microbes, viruses, bacteria, and other harmful pathogens.
  • TACTICS: Manage unique leukocytes using their tactical advantages against the various pathogens, infecting the host.
  • CATALOG: A log of medical descriptions of the types of immune cells, pathogens, and processes within the body.
  • IMPROVEMENTS: To build a more effective defense, you may build improvements into the defenses of the immune system.
  • ATMOSPHERIC MUSIC: Featuring an original soundtrack from Nuclear Mushroom Boom!

What Steam players say

Recent verbatim reviews from Steam — separate from playze.io community reviews below.

Recommended May 20, 2025
Fun and casual tower defense game that teaches you a bit about the immune system! Levels are short but entertaining so it's perfect for short play sessions. I like the varied backgrounds and the units are cute & well animated. There is a story you can see play out in the background, but to be honest I couldn't pay much attention to it so far. The only complaint I have is that the units' in-game capabilities could be explained better. It's not too hard to figure out on your own, but it would make getting back into the game easier if you could easily see the enemy movement patterns and attacks in the journal. Overall Listeria Wars is great to pass a few minutes here and there!
2 found this helpful
Recommended Aug 19, 2023
Great game! I loved the art and the music so much, the game play is very addictive and challenging. The idea is super original so recommended 10/10
2 found this helpful
Recommended Aug 18, 2023
Tapping in to the simple appeal of Tower Defence, this is solo dev's Rubel Games first game. Using a classic pixel art style, the game possesses a nostalgic charm. Listeria wars has graphics and music that remind me of early Xbox Arcade games (a good thing). The gameplay is simple but massively satisfying, providing a twist on old mechanics with the ability to move units on the fly similar to an RTS A lot of love clearly went into this game. A competent and unique Tower Defence game in the guise of an achievement baby game.
2 found this helpful
Recommended Jun 30, 2023
Nice little tower defense game that I apparently suck at :D
2 found this helpful
Recommended Mar 9, 2026
peak
Recommended May 2, 2025
Pixel art, chiptune and tower defence - all the things that I love in one place.

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